MAGNESIUM DIPROPYLACETATE HYDRATE Property

Melting point:

>294°C (dec.)

storage temp. 

Refrigerator

solubility 

Ethyl Acetate (Slightly), Methanol (Slightly), Water (Slightly)

form 

Solid

color 

White

CAS DataBase Reference

62959-43-7

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H360May damage fertility or the unborn child

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

MAGNESIUM DIPROPYLACETATE HYDRATE Chemical Properties,Usage,Production

Uses

Magnesium Valproate is an anticonvulsant agent and the effects it exerts are the result of valproic acid and magnesium acting in a complementary way. Magnesium valproate is effective as monotherapy in patients with newly diagnosed or previously treated partial or generalised epilepsy.

Uses

Antiepileptic

Trade name

Logical (Armstrong)

Safety Profile

Moderately toxic by ingestion. Danger: A spontaneously combustible solid. When heated to decomposition it emits toxic vapors of magnesium.

Synthesis

Diethyl malonate is alkylated with 1-bromopropane and then hydrolyzed and decarboxylated to afford Magnesium valproate.

Description

Valproic acid and its salt Magnesium Valproate is major antiepileptic drugs for the treatment of absence, myoclonic, and generalized tonic – clonic seizures and also may be effective against complex partial seizures. The most cited mechanisms are the increase in GABA function and the blockade of voltage-dependent Na+-channels. The most common side effects are gastrointestinal disturbances and sedation. The most serious adverse effect is liver damage, although this is rare. Teratogenic effects, predominantly spina bifida, are reported frequently.